Immune tolerance in liver disease
نویسندگان
چکیده
منابع مشابه
Lowered Immune Cell Function in Liver Recipients Recovered From Posttransplant Lymphoproliferative Disease Who Developed Graft Tolerance
UNLABELLED Tolerance after treatment and recovery from posttransplant lymphoproliferative disease (PTLD) have been described but little is known about the immunology. The objective of this study is to evaluate the immunity of pediatric recipients who recovered from PTLD. MATERIALS AND METHODS Pediatric recipients who recovered from PTLD after liver transplant and twice the number of recipient...
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The chemokine receptor CXCR3 is preferentially expressed by Th1 cells and critically involved in their recruitment to inflamed tissue. In a mouse model of immune-mediated liver injury inducible by Con A, we investigated the role of CXCR3 in acute IFN-γ-mediated hepatitis as well as in tolerance induction, which has been shown to depend on IL-10-producing CD4(+)CD25(+)Foxp3(+) regulatory T cells...
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Liver transplantation is the most effective treatment for endstage liver diseases with satisfactory clinical results. Unfortunately, adverse effects of life-long immunosuppression prevent the development of alternative strategies to achieve better long-term outcome. Achieving clinical operational tolerance is the ultimate goal in the clinical transplantation field. Around 15% of liver transplan...
متن کاملCell-mediated immune reactivity in liver disease.
Cell-mediated immunity has been investigated using the leucocyte migration test in 32 patients with chronic active hepatitis or primary biliary cirrhosis. Twenty-six (75%) showed reactivity to liver extract. At least two antigens are involved. Cell-mediated reactivity was confirmed in some cases using lymphocyte ;blast' transformation. There was no correlation with the presence of auto-antibodi...
متن کاملAlcoholic Liver Disease And Immune Response
The alcoholic liver disease (ALD) continues to be a major health problem worldwide with respect to both morbidity and mortality. It is usually an outcome of excessive alcohol consumptions but can be worse by poor diet and genetic factors. This review aims to update the recent conditions of the epidemiology, pathogenesis, immune response and therapies to ALD. The new insights into the pathogenes...
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ژورنال
عنوان ژورنال: Hepatology
سال: 2014
ISSN: 0270-9139,1527-3350
DOI: 10.1002/hep.27254